Photoresponsive Inorganic Nanocarriers for Image Guided Drug Delivery

Generally, photoresponsive nanoparticles for drug delivery are constructed using two main ingredients: biocompatible nanoparticles and photoremovable protecting groups, which are nothing but small organic molecules which are able to release active molecule in presence of light. To date, the nominee has developed various photoresponsive nanoparticles such as coumarin tethered Fe/Si magnetic nanoparticles, quinoline decorated mesoporous silica nanoparticles, quinoline bounded carbon dots and silicon quantum dots for image guided drug delivery in vitro. With these newly developed functionalized organic and inorganic nanoparticles our group has shown efficient cell targeted drug delivery, nuclear targeted drug delivery via charge reversal and real time monitoring of the drug release via in vitro experiments.